Promoter analysis and aberrant expression of MUC5B gene in diffuse panbronchiolitis
نویسندگان
چکیده
a. Department of Respiratory Diseases, Research Institute, International Medical Center of Japan, Tokyo, Japan; b. Fourth Department of Internal Medicine, Nippon Medical School, Tokyo, Japan; c. Unit of Human Biology and Genetics, Department of Biological Sciences, Graduate School of Science, University of Tokyo, Tokyo, Japan; d. Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan; e. The Department of Pathology, Tenri Hospital, Nara, Japan; f. The Department of Respiratory Medicine, Tenri Hospital, Nara, Japan; g. Department of Respiratory Medicine, Respiratory Center, Toranomon Hospital, Tokyo, Japan; h. Department of Pulmonary Medicine, Toho University School of Medicine, Tokyo, Japan;
منابع مشابه
Promoter analysis and aberrant expression of the MUC5B gene in diffuse panbronchiolitis.
Diffuse panbronchiolitis (DPB) is a chronic inflammatory airway disease predominantly affecting Asian populations. DPB is considered to be a complex genetic disease. Considering the mucous hypersecretion of the disease, we hypothesized that the transcriptional activity of mucin genes may be altered in DPB. We analyzed nucleotide sequences of regulatory region of six mucin genes--MUC1, MUC2, MUC...
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